Variation within 3' UTRs of base excision repair genes and response to therapy in colorectal cancer patients: a potential modulation of microRNAs binding.

0398199 - ÚEM 2014 RIV US eng J - Článek v odborném periodiku
Pardini, B. - Rosa, F. - Barone, E. - Di Gaetano, C. - Slyšková, Jana - Novotný, J. - Levý, M. - Garritano, S. - Vodičková, Ludmila - Buchler, T. - Gemignani, F. - Landi, S. - Vodička, Pavel - Naccarati, Alessio
Variation within 3' UTRs of base excision repair genes and response to therapy in colorectal cancer patients: a potential modulation of microRNAs binding.
Clinical Cancer Research. Roč. 19, č. 21 (2013), s. 6044-6056. ISSN 1078-0432. E-ISSN 1557-3265
Grant CEP: GA ČR GAP304/10/1286; GA ČR(CZ) GAP304/12/1585
Institucionální podpora: RVO:68378041
Klíčová slova: colorectal cancer * base excision repair * survival
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 8.193, rok: 2013

This study comprehensively evaluated the associations between SNPs in microRNA target binding sites of BER genes and clinical outcomes in colorectal cancer (CRC) patients. Variations in the SMUG1 gene provided biologically plausible predictors of survival, with an additional effect of 5-FU chemotherapy.
Trvalý link: http://hdl.handle.net/11104/0225720