Počet záznamů: 1  

The impact of four different classes of anesthetics on the mechanisms of blood pressure regulation in normotensive and spontaneously hypertensive rats

  1. 1.
    0399942 - FGÚ 2014 RIV CZ eng J - Článek v odborném periodiku
    Bencze, Michal - Behuliak, Michal - Zicha, Josef
    The impact of four different classes of anesthetics on the mechanisms of blood pressure regulation in normotensive and spontaneously hypertensive rats.
    Physiological Research. Roč. 62, č. 5 (2013), s. 471-478. ISSN 0862-8408. E-ISSN 1802-9973
    Grant CEP: GA ČR(CZ) GAP304/12/0259
    Výzkumný záměr: CEZ:AV0Z50110509
    Institucionální podpora: RVO:67985823
    Klíčová slova: sympathetic nervous system * renin-angiotensin system * nitric oxide
    Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
    Impakt faktor: 1.487, rok: 2013

    We studied the influence of four widely used anesthetics - pentobarbital (P), isoflurane (ISO), ketamine-xylazine (KX) and chloralose-urethane (CU) - on the participation of renin-angiotensin system (RAS), sympathetic nervous system (SNS) and nitric oxide (NO) in BP maintenance. In conclusion, pentobarbital anesthesia had a modest influence on BP level and its maintenance by the above vasoactive systems. Isoflurane and chloralose-urethane anesthesia may be used in cardiovascular experiments if substantial BP decrease due to altered contribution of RAS, SNS and NO to BP regulation does not interfere with the respective research aim. Major BP reduction (namely in SHR) due to a complete SNS absence is a major drawback of ketamine-xylazine anesthesia
    Trvalý link: http://hdl.handle.net/11104/0227115

     
     
Počet záznamů: 1  

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