Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications

0420861 - FGÚ 2014 RIV US eng J - Článek v odborném periodiku
Boulos, J. - Jakubík, Jan - Randáková, Alena - Avila, C.
Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications.
Journal of Heterocyclic Chemistry. Roč. 50, č. 6 (2013), s. 1363-1367. ISSN 0022-152X. E-ISSN 1943-5193
Grant CEP: GA ČR(CZ) GA305/09/0681
Institucionální podpora: RVO:67985823
Klíčová slova: N-piperidine substituted salts * muscarinic receptor antagonists * selectivity
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 0.873, rok: 2013

Several heterocyclic N-piperidine substituted salts were synthesized that were found to inhibit the specific binding of the antagonists of muscarinic receptors. One of the compounds was found tobe 3 to 8 times more potent at M2 than other subtypes of muscarinic receptors in competition binding and selective for the M1 receptors over M3 and M5 in antagonizing accumulation of inositol phosphates induced by muscarinic agonist carbachol
Trvalý link: http://hdl.handle.net/11104/0227397