Počet záznamů: 1
Long-Term Activation upon Brief Exposure to Xanomleline Is Unique to M1 and M4 Subtypes of Muscarinic Acetylcholine Receptors
- 1.0427640 - FGÚ 2015 RIV US eng J - Článek v odborném periodiku
Šantrůčková, Eva - Doležal, Vladimír - El-Fakahany, E. E. - Jakubík, Jan
Long-Term Activation upon Brief Exposure to Xanomleline Is Unique to M1 and M4 Subtypes of Muscarinic Acetylcholine Receptors.
PLoS ONE. Roč. 9, č. 2 (2014), e88910. ISSN 1932-6203. E-ISSN 1932-6203
Grant CEP: GA ČR(CZ) GA305/09/0681; GA ČR(CZ) GAP304/12/0259
Výzkumný záměr: CEZ:AV0Z50110509
Institucionální podpora: RVO:67985823
Klíčová slova: muscarinic receptors * functional selectivity * xanomeline
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 3.234, rok: 2014
Long-term receptor activation by xanomeline takes place in full only at M1 and M4 muscarinic receptors. Xanomeline displays higher efficacy at M1 and M4 receptors in primary phasic intracellular calcium release. These findings suggest the existence of particular activation mechanisms specific to these two receptor subtypes
Trvalý link: http://hdl.handle.net/11104/0233140
Počet záznamů: 1