Počet záznamů: 1
Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful?
- 1.0428039 - FGÚ 2015 RIV CZ eng J - Článek v odborném periodiku
Boukalová, Štěpána - Touška, Filip - Maršáková, Lenka - Hynková, Anna - Surá, Lucie - Chvojka, Štěpán - Dittert, Ivan - Vlachová, Viktorie
Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful?
Physiological Research. Roč. 63, Suppl.1 (2014), S205-S213. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GA305/09/0081; GA ČR(CZ) GBP304/12/G069
Grant ostatní: Univerzita Karlova(CZ) 500512; Univerzita Karlova(CZ) 888513
Institucionální podpora: RVO:67985823
Klíčová slova: transient receptor potential * ion channel * mutagenesis * vanilloid receptor * gating
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 1.293, rok: 2014
Gain-of-function (GOF) mutations in ion channels are rare events, which lead to increased agonist sensitivity or altered gating properties, and may render the channel constitutively active. Here we give an overview of some GOF mutants in polymodal ion channels specifically involved in transduction of painful stimuli – TRPV1 and TRPA1, which are scrutinized by scientists due to their important role in development of some pathological pain states
Trvalý link: http://hdl.handle.net/11104/0233479
Počet záznamů: 1