Počet záznamů: 1
Mitochondrial membrane assembly of TMEM70 protein
- 1.0428880 - FGÚ 2015 RIV NL eng J - Článek v odborném periodiku
Kratochvílová, H. - Hejzlarová, Kateřina - Vrbacký, Marek - Mráček, Tomáš - Karbanová, Vendula - Tesařová, M. - Gombitová, A. - Cmarko, D. - Wittig, I. - Zeman, J. - Houštěk, Josef
Mitochondrial membrane assembly of TMEM70 protein.
Mitochondrion. Roč. 15, Mar 2014 (2014), s. 1-9. ISSN 1567-7249. E-ISSN 1872-8278
Grant CEP: GA ČR(CZ) GAP303/11/0970; GA MŠk(CZ) LL1204; GA ČR(CZ) GB14-36804G
Institucionální podpora: RVO:67985823
Klíčová slova: mitochondria * ATP synthase * TMEM70 * biogenesis
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.249, rok: 2014
Dysfunction of TMEM70 disrupts the biogenesis of ATP synthase and represents the frequent cause of autosomal recessive encephalocardiomyopathy. In this study we demonstrate, that TMEM70 protein has a hairpin structure with the N- and C- termini oriented towards the mitochondrial matrix, and is capable to form oligomeric structures partly overlapping with ATP synthase, nevertheless the direct interaction between TMEM70 and ATP synthase complex or assembly subcomplexes was not found. Our data represent an important basis for further characterization of the biological function of TMEM70 factor that could be mediated through interaction with some other protein(s)
Trvalý link: http://hdl.handle.net/11104/0234111
Počet záznamů: 1