Pharmacogenetic Analysis of Captopril Effects on Blood Pressure: Possible Role of the Ednrb (Endothelin Receptor Type B) Candidate Gene

0428969 - FGÚ 2015 RIV CZ eng J - Článek v odborném periodiku
Zicha, Josef - Dobešová, Zdenka - Zídek, Václav - Šilhavý, Jan - Šimáková, Miroslava - Mlejnek, Petr - Vaněčková, Ivana - Kuneš, Jaroslav - Pravenec, Michal
Pharmacogenetic Analysis of Captopril Effects on Blood Pressure: Possible Role of the Ednrb (Endothelin Receptor Type B) Candidate Gene.
Physiological Research. Roč. 63, č. 2 (2014), s. 263-265. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MŠMT(CZ) LH11049
Institucionální podpora: RVO:67985823
Klíčová slova: captopril * blood pressure * QTL * Ednrb gene * spontaneously hypertensive rat
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.293, rok: 2014

The objective of the current study was to search for genetic determinants associated with antihypertensive effects of angiotensin-converting enzyme (ACE) inhibitor captopril. Linkage analysis of captopril-induced blood pressure effects revealed a significant quantitative trait locus (QTL) on chromosome 15 near Ednrb candidate gene. These results suggest that blood pressure lowering effects of ACE inhibitor captopril may be modulated by the variants at the Ednrb locus
Trvalý link: http://hdl.handle.net/11104/0234189