Počet záznamů: 1  

Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction

  1. 1.
    0433305 - FGÚ 2015 RIV US eng J - Článek v odborném periodiku
    Houštěk, Josef - Vrbacký, Marek - Hejzlarová, Kateřina - Zídek, Václav - Landa, Vladimír - Šilhavý, Jan - Šimáková, Miroslava - Mlejnek, Petr - Kazdová, L. - Mikšík, Ivan - Neckář, Jan - Papoušek, František - Kolář, František - Kurtz, T. W. - Pravenec, Michal
    Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction.
    Physiological Genomics. Roč. 46, č. 18 (2014), s. 671-678. ISSN 1094-8341. E-ISSN 1531-2267
    Grant CEP: GA MŠk(CZ) LL1204; GA ČR(CZ) GB14-36804G; GA ČR(CZ) GA13-10267S; GA MŠk(CZ) 7E10067
    Institucionální podpora: RVO:67985823
    Klíčová slova: SHR conplastic strain with F344 mtDNA * impaired glucose tolerance * systolic dysfunction
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Impakt faktor: 2.374, rok: 2014

    In the current study, we investigated the metabolic and hemodynamic effects of the SHR versus F344 mtDNA by comparing the SHR versus SHR-mtF344 conplastic strains that are genetically identical except for their mitochondrial genomes. Altogether 13 amino acid substitutions in protein coding genes, 7 single nucleotide polymorphisms in tRNA genes and 12 single nucleotide changes in rRNA genes were detected in F344 mtDNA when compared to SHR mtDNA. Analysis of oxidative phosphorylation system (OXPHOS) in heart left ventricles (LV), muscle and liver revealed reduced activity and content of several respiratory chain complexes in SHR-mtF344 conplastic rats when compared to the SHR strain. Lower function of OXPHOS in LV of conplastic rats was associated with significantly increased relative ventricular mass and reduced fractional shortening which was independent of blood pressure
    Trvalý link: http://hdl.handle.net/11104/0237598

     
     
Počet záznamů: 1  

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