Počet záznamů: 1
Different effects of lobeline on neuronal and muscle nicotinic receptors
- 1.0437656 - FGÚ 2015 RIV NL eng J - Článek v odborném periodiku
Kaniaková, Martina - Skřenková, Kristýna - Adámek, S. - Vyskočil, František - Krůšek, Jan
Different effects of lobeline on neuronal and muscle nicotinic receptors.
European Journal of Pharmacology. Roč. 738, Sep 5 (2014), s. 352-359. ISSN 0014-2999. E-ISSN 1879-0712
Grant CEP: GA ČR(CZ) GA202/09/0806; GA AV ČR(CZ) IAA500110905; GA ČR(CZ) GBP304/12/G069
Institucionální podpora: RVO:67985823
Klíčová slova: neuronal nicotinic receptor alpha3beta4 * lobeline * embryonic muscle nicotinic receptor
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 2.532, rok: 2014
The effect of lobeline on two model types of nicotinic receptors was studied using the patch-clamp technique. Our results show that lobeline inhibits responses to acetylcholine in human embryonic muscle alpha beta gamma delta receptor naturally expressed in TE671 cells in a pseudo-noncompetitive manner. On the neuronal alpha3beta4 nicotinic receptor expressed in COS cells the effect of lobeline is more complex and depends on the concentration of the agonist acetylcholine
Trvalý link: http://hdl.handle.net/11104/0241163
Počet záznamů: 1