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Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?
- 1.0439022 - MBÚ 2015 RIV GB eng J - Článek v odborném periodiku
Romero, Rodrigo, Villarino - Osička, Radim - Šebo, Peter
Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?
Future Microbiology. Roč. 9, č. 12 (2014), s. 1339-1360. ISSN 1746-0913. E-ISSN 1746-0921
Grant CEP: GA ČR(CZ) P302/11/0580; GA ČR(CZ) GA13-14547S
Institucionální podpora: RVO:61388971
Klíčová slova: Bordetella * adhesion * integrins * filamentous hemagglutinin
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 4.275, rok: 2014
The filamentous hemagglutinin of pathogenic Bordetellae is a prototype of a large two-partner-system-secreted and beta-structure-rich bacterial adhesin. It exhibits several binding activities that may facilitate bacterial adherence to airway mucosa and host phagocytes in the initial phases of infection. Despite three decades of research on filamentous hemagglutinin, there remain many questions on its structure-function relationships, integrin interactions and possible immunomodulatory signaling capacity. Here we review the state of knowledge on this important virulence factor and acellular pertussis vaccine component. Specific emphasis is placed on outstanding questions that are yet to be answered.
Trvalý link: http://hdl.handle.net/11104/0242399
Počet záznamů: 1