Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study

0440505 - ÚEM 2015 RIV GB eng J - Článek v odborném periodiku
White, A. J. - Teitelbaum, S. L. - Stellman, S. D. - Beyea, J. - Steck, S. E. - Mordukhovich, I. - McCarty, K. M. - Ahn, J. - Rössner ml., Pavel - Santella, R. M. - Gammon, M. D.
Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study.
Environmental Health: A Global Access Science Source. Roč. 13, Dec 12 (2014), s. 108. E-ISSN 1476-069X
Institucionální podpora: RVO:68378041
Klíčová slova: polycyclic aromatic hydrocarbons * GST * cancer
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 3.372, rok: 2014

The cells were treated for 24 h with B[a]P (1 μM, 10 μM, 25 μM) and EOMs (1 μg/ml, 10 μg/ml, 25 μg/ml). 25 μM of B[a]P and most of the tested doses of EOMs induced double strand breaks (DSBs) as indicated by H2AX phosphorylation. DNA damage was accompanied by induction of XRCC4 expression and an increased frequency of chromosomal aberrations. Translocations most frequently affected chromosome 7. We observed only a weak induction of Ku70/80 expression as well as ligation activity of nuclear extracts.
Trvalý link: http://hdl.handle.net/11104/0243915