Počet záznamů: 1
The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor
- 1.0440989 - FGÚ 2015 RIV CZ eng J - Článek v odborném periodiku
Šepsová, V. - Krůšek, Jan - Zdarová Karasová, J. - Zemek, F. - Musílek, K. - Kuča, K. - Soukup, O.
The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor.
Physiological Research. Roč. 63, č. 6 (2014), s. 771-777. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GBP304/12/G069
Institucionální podpora: RVO:67985823
Klíčová slova: acetylcholinesterase inhibitor * nicotin receptor
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 1.293, rok: 2014
Acetylcholinesterase inhibitors (AChEIs) are used in the treatment of myasthenia gravis (MG). We investigated the direct effects of selected AChEIs on muscle nicotinic receptors (nAChR). The whole-cell mode of the patch-clamp method was employed in experiments on cell line TE671 expressing human embryonic muscle receptors. No positive modulation of muscle receptor activity was observed, all compounds caused inhibition
Trvalý link: http://hdl.handle.net/11104/0244064
Počet záznamů: 1