Počet záznamů: 1  

A Hydrophobic Filter Confers the Cation Selectivity of Zygosaccharomyces rouxii Plasma-Membrane Na (+)/H (+) Antiporter

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    0444083 - FGÚ 2016 RIV GB eng J - Článek v odborném periodiku
    Kinclová-Zimmermannová, Olga - Falson, P. - Cmunt, Denis - Sychrová, Hana
    A Hydrophobic Filter Confers the Cation Selectivity of Zygosaccharomyces rouxii Plasma-Membrane Na (+)/H (+) Antiporter.
    Journal of Molecular Biology. Roč. 427, č. 8 (2015), s. 1681-1697. ISSN 0022-2836. E-ISSN 1089-8638
    Grant CEP: GA ČR(CZ) GAP503/10/0307; GA MŠk(CZ) LD13037
    Institucionální podpora: RVO:67985823
    Klíčová slova: yeast * plasma membrane * sodium proton exchanger * substrate specificity * potassium transport
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 4.517, rok: 2015

    Na+/H+ antiporters may recognize all alkali metal cations as substrates, but transport them selectively. Plasma-membrane Zygosaccharomyces rouxii Sod2-22 antiporter exports Na+ and Li+, but not K+. A 3D model of the ZrSod2-22 transmembrane domain was generated and suggested a close proximity of Thr141, Ala179 and Val375 from transmembrane segments 4, 5 and 11, respectively, forming a hydrophobic hole in the putative cation pathway’s core. Obtained experimental results confirmed that the three residues found through modelling play a central role in the determination of cation selectivity and transport activity in Z. rouxii Na+/H+ antiporter, and that the cation selectivity can be modulated by repositioning a single local methyl group
    Trvalý link: http://hdl.handle.net/11104/0246683

     
     
Počet záznamů: 1  

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