Počet záznamů: 1  

Rosuvastatin ameliorates inflammation, renal fat accumulation, and kidney injury in transgenic spontaneously hypertensive rats expressing human C-reactive protein

  1. 1.
    0446300 - FGÚ 2016 RIV CZ eng J - Článek v odborném periodiku
    Šilhavý, Jan - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Mlejnek, Petr - Oliyarnyk, O. - Malínská, H. - Kazdová, L. - Mancini, M. - Pravenec, Michal
    Rosuvastatin ameliorates inflammation, renal fat accumulation, and kidney injury in transgenic spontaneously hypertensive rats expressing human C-reactive protein.
    Physiological Research. Roč. 64, č. 3 (2015), s. 295-301. ISSN 0862-8408. E-ISSN 1802-9973
    Grant CEP: GA MŠk(CZ) LH11049; GA MŠk(CZ) LL1204; GA MZd(CZ) NT14325; GA ČR(CZ) GB14-36804G
    Institucionální podpora: RVO:67985823
    Klíčová slova: rosuvastatin * kidney damage * CRP * transgenic * spontaneously hypertensive rat
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 1.643, rok: 2015

    Recently, we derived “humanized” spontaneously hypertensive rats (SHR-CRP) in which transgenic expression of human CRP induces inflammation, oxidative stress, several features of metabolic syndrome and target organ injury. In the current study, we tested the effects of rosuvastatin on kidney injury in SHR-CRP males versus untreated SHR-CRP and SHR controls. In SHR-CRP transgenic rats, treatment with rosuvastatin, compared to untreated transgenic rats and SHR controls, was associated with significantly reduced systemic inflammation which was accompanied with activation of antioxidative enzymes in the kidney and with amelioration of histopathological changes in the kidney. These findings provide evidence that, in the presence of high CRP levels, rosuvastatin exhibits significant anti-inflammatory, anti-oxidative, and renoprotective effects
    Trvalý link: http://hdl.handle.net/11104/0248280

     
     
Počet záznamů: 1  

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