Počet záznamů: 1  

Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model

  1. 1.
    0448049 - BÚ 2016 RIV US eng J - Článek v odborném periodiku
    Sovadinová, I. - Babica, Pavel - Böke, H. - Kumar, E. - Wilke, A. - Park, J.-S. - Trosko, J. E. - Upham, B. L.
    Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model.
    PLoS ONE. Roč. 10, 5 no.e0124454 (2015), s. 1-16. ISSN 1932-6203. E-ISSN 1932-6203
    Grant CEP: GA MŠk LH12034
    Institucionální podpora: RVO:67985939
    Klíčová slova: gap junctional intercellular communication * resveratrol * phosphatidylcholine-specific phospholipase C
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 3.057, rok: 2015

    Dysregulation of gap junctional intercellular communication (GJIC) has been associated with different pathologies, including cancer; however, molecular mechanisms regulating GJIC are not fully understood. Mitogen Activated Protein Kinase (MAPK)-dependent mechanisms of GJIC-dysregulation have been well-established, however recent discoveries have implicated phosphatidylcholine-specific phospholipase C (PC-PLC) in the regulation of GJIC. What is not known is how prevalent these two signaling mechanisms are in toxicant/toxin-induced dysregulation of GJIC, and do toxicants/toxins work through either signaling mechanisms or both, or through alternative signaling mechanisms. In conclusion: the dysregulation of GJIC is a contributing factor to the cancer process; however the underlying mechanisms by which gap junction channels are closed by toxicants vary. Thus, accurate assessments of risk posed by toxic agents, and the role of dietary phytochemicals play in preventing or reversing the effects of these agents must take into account the specific mechanisms involved in the cancer process.
    Trvalý link: http://hdl.handle.net/11104/0249785

     
     
Počet záznamů: 1  

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