Počet záznamů: 1
Carnitine supplementation alleviates lipid metabolism derangements and protects against oxidative stress in non-obese hereditary hypertriglyceridemic rats
- 1.0448355 - FGÚ 2016 RIV CA eng J - Článek v odborném periodiku
Cahová, M. - Chrastina, P. - Hansíková, H. - Drahota, Zdeněk - Trnovská, J. - Škop, V. - Spáčilová, J. - Malínská, H. - Oliyarnyk, O. - Papáčková, Z. - Páleníčková, E. - Kazdová, L.
Carnitine supplementation alleviates lipid metabolism derangements and protects against oxidative stress in non-obese hereditary hypertriglyceridemic rats.
Applied Physiology Nutrition and Metabolism-Physiologie appliquee nutrition et metabolisme. Roč. 40, č. 3 (2015), s. 280-291. ISSN 1715-5312. E-ISSN 1715-5320
Grant CEP: GA MŠk(CZ) LL1204; GA ČR(CZ) GB14-36804G
Institucionální podpora: RVO:67985823
Klíčová slova: metabolic syndrome * insulin resistance * antioxidant * liver steatosis * mass spectrometry
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.910, rok: 2015
The aim of this study was to estimate the effect of carnitine supplementation on lipid disorders and peripheral tissue insulin sensitivity in the hereditary hypertriglyceridemic (HHTg) rat. Male HHTg rats were fed a standard diet, and half of them received daily doses of carnitine (500 mg·kg−1 body weight) for 8 weeks. HHTg rats exhibited increased urinary excretion of free carnitine and reduced carnitine content in the liver and blood. Carnitine supplementation compensated for this shortage and promoted urinary excretion of acetylcarnitine without any signs of (acyl)carnitine accumulation in skeletal muscle. Carnitine-treated HHTg rats exhibited lower weight gain, reduced liver steatosis, lower fasting triglyceridemia, and greater reduction of serum free fatty acid content after glucose load. Carnitine treatment was associated with increased mitochondrial biogenesis and oxidative capacity for fatty acids, amelioration of oxidative stress, and restored substrate switching in the liver. In skeletal muscle, carnitine supplementation was associated with significantly higher palmitate oxidation and a more favorable complete to incomplete oxidation products ratio. Carnitine supplementation further enhanced insulin sensitivity ex vivo. No effects on whole-body glucose tolerance were observed. Our data suggest that some metabolic syndrome-related disorders, particularly fatty acid oxidation, steatosis, and oxidative stress in the liver, could be attenuated by carnitine supplementation via increased fatty acid transport from tissues in the form of short-chain acylcarnitines
Trvalý link: http://hdl.handle.net/11104/0250083
Počet záznamů: 1