Can Nucleoli Be Markers of Developmental Potential in Human Zygotes?

0455801 - ÚMG 2016 RIV GB eng J - Článek v odborném periodiku
Fulka, Helena - Kyogoku, H. - Zatsepina, O. - Langerova, A. - Fulka, J.
Can Nucleoli Be Markers of Developmental Potential in Human Zygotes?
Trends in Molecular Medicine. Roč. 21, č. 11 (2015), s. 663-672. ISSN 1471-4914. E-ISSN 1471-499X
Grant ostatní: GA ČR GA13-03269S
Institucionální podpora: RVO:68378050 ; RVO:67985904
Klíčová slova: human zygotes * developmental potential * nucleoli
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 9.292, rok: 2015

In 1999, Tesarik and Greco reported that they could predict the developmental potential of human zygotes from a single static evaluation of their pronuclei. This was based on the distribution and number of specific nuclear organelles - the nucleoli. Recent studies in mice show that nucleoli play a key role in parental genome restructuring after fertilization, and that interfering with this process may lead to developmental failure. These studies thus support the Tesarik-Greco evaluation as a potentially useful method for selecting high-quality embryos in human assisted reproductive technologies. In this opinion article we discuss recent evidence linking nucleoli to parental genome reprogramming, and ask whether nucleoli can mirror or be used as representative markers of embryonic parameters such as chromosome content or DNA fragmentation.
Trvalý link: http://hdl.handle.net/11104/0256418