Počet záznamů: 1
Adverse Effects of AMP-Activated Protein Kinase alpha 2-Subunit Deletion and High-Fat Diet on Heart Function and Ischemic Tolerance in Aged Female Mice
- 1.0458524 - FGÚ 2017 RIV CZ eng J - Článek v odborném periodiku
Slámová, Kristýna - Papoušek, František - Janovská, Petra - Kopecký, Jan - Kolář, František
Adverse Effects of AMP-Activated Protein Kinase alpha 2-Subunit Deletion and High-Fat Diet on Heart Function and Ischemic Tolerance in Aged Female Mice.
Physiological Research. Roč. 65, č. 1 (2016), s. 33-42. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GB14-36804G
Institucionální podpora: RVO:67985823
Klíčová slova: AMP kinase * ischemia/reperfusion * myocardial infarction * aging * high-fat diet
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.461, rok: 2016
AMPK alpha2-/- (KO) and wild type (WT) female mice were compared at the age of 6 and 18 months. Left ventricular fractional shortening was lower in KO than in WT mice of both age groups and this difference was maintained after high-fat feeding. Infarct size induced by global ischemia/reperfusion of isolated hearts was similar in both strains at 6 months of age. High-fat feeding for 6 months during aging abolished the infarct size-reduction in WT without affecting KO animals; nevertheless, the extent of injury remained larger in KO mice. The results demonstrate that adverse effects of AMPK alpha2-subunit deletion and high-fat feeding on heart function and myocardial ischemic tolerance in aged female mice are not additive.
Trvalý link: http://hdl.handle.net/11104/0258785
Počet záznamů: 1