Počet záznamů: 1
Pathogenic Candida species differ in the ability to grow at limiting potassium concentrations
- 1.0459569 - FGÚ 2017 RIV CA eng J - Článek v odborném periodiku
Hušeková, Barbora - Elicharová, Hana - Sychrová, Hana
Pathogenic Candida species differ in the ability to grow at limiting potassium concentrations.
Canadian Journal of Microbiology. Roč. 62, č. 5 (2016), s. 394-401. ISSN 0008-4166. E-ISSN 1480-3275
Grant CEP: GA ČR(CZ) GAP302/12/1151; GA MŠk(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:67985823
Klíčová slova: Candida * potassium homeostasis * morphology
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 1.462, rok: 2016
A high intracellular concentration of potassium (200–300 mmol/L) is essential for many yeast cell functions, such as the regulation of cell volume and pH, maintenance of membrane potential, and enzyme activation. Thus, cells use high-affinity specific transporters and expend a lot of energy to acquire the necessary amount of potassium from their environment. In Candida genomes, genes encoding 3 types of putative potassium uptake systems were identified: Trk uniporters, Hak symporters, and Acu ATPases. Tests of the tolerance and sensitivity of C. albicans, C. dubliniensis, C. glabrata, C. krusei, C. parapsilosis, and C. tropicalis to various concentrations of potassium showed significant differences among the species, and these differences were partly dependent on external pH. The species most tolerant to potassium-limiting conditions were C. albicans and C. krusei, while C. parapsilosis tolerated the highest KCl concentrations. Taken together, our results confirm potassium uptake and accumulation as important factors for Candida cell growth and suggest that the sole (and thus probably indispensable) Trk1 potassium uptake system in C. krusei and C. glabrata may serve as a target for the development of new antifungal drugs.
Trvalý link: http://hdl.handle.net/11104/0259749
Počet záznamů: 1