Nucleophilic Tetrafluoroethylation Employing in Situ Formed Organomagnesium Reagents

0467402 - ÚOCHB 2017 RIV US eng J - Článek v odborném periodiku
Budinská, Alena - Václavík, Jiří - Matoušek, V. - Beier, Petr
Nucleophilic Tetrafluoroethylation Employing in Situ Formed Organomagnesium Reagents.
Organic Letters. Roč. 18, č. 22 (2016), s. 5844-5847. ISSN 1523-7060. E-ISSN 1523-7052
Institucionální podpora: RVO:61388963
Klíčová slova: enantioselective synthesis * fluorinated sulfones * organic synthesis
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 6.579, rok: 2016

Tetrafluoroalkyl bromides are metalated with equi-molar iPrMgCl.LiCl (Turbo Grignard) to form organomagnesium compounds which are stable at low temperatures and react with various electrophiles (aldehydes, ketones, CO2, cyclic sulfate and sulfamidate, N-sulfonylimines, nitrone, chlorophosphate, nonaflyl azide) to afford novel functionalized tetrafluoroethylene-containing products. Ease of operation, excellent selectivity, high nucleophilicity, and enhanced stability of the reactive species together with a broad substrate scope comprise a highly attractive nudeophilic tetrafluoroethylation protocol affording unique synthetic building blocks.
Trvalý link: http://hdl.handle.net/11104/0265506