One OdontogenicCell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule

0470568 - ÚEM 2017 RIV US eng J - Článek v odborném periodiku
Hovořáková, Mária - Lochovská, Kateřina - Zahradníček, Oldřich - Domonkosová Tibenská, K. - Dornhoferová, M. - Horáková Smrčková, Lucie - Bodoriková, S.
One OdontogenicCell-Population Contributes to the Development of the Mouse Incisors and of the Oral Vestibule.
PLoS ONE. Roč. 11, č. 9 (2016), e0162523. ISSN 1932-6203. E-ISSN 1932-6203
Grant CEP: GA ČR(CZ) GAP305/12/1766
Institucionální podpora: RVO:68378041
Klíčová slova: deciduous dentition * tooth development * human embryos
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.806, rok: 2016

The area of the oral vestibule is often a place where pathologies appear (e.g., peripheral odontomas). The origin of these pathologies is not fully understood. In the present study, we traced a cell population expressing Sonic hedgehog (Shh) from the beginning of tooth development using Cre-LoxP system in the lower jaw of wild-type (WT) mice. We focused on Shh expression in the area of the early appearing rudimentaryincisor germs located anteriorly to the prospective incisors. The localization of the labelled cells in the incisor germs and also in the inner epithelial layer of the vestibular anlage showed that the first very early developmental events in the lower incisor area are common to the vestibulum oris and the prospective incisor primordia in mice. Scanning electron microscopic analysis of human historical tooth-like structures found in the vestibular area of jaws confirmedtheir relation to teeth and thus the capability of the vestibular tissue to form teeth. The location of labelled cells descendant of the early appearing Shh expression domain related to the rudimentary incisor anlage not only in the rudimentary and functional incisor germs but also in the externally located anlage of the oral vestibule documented the odontogenic potential of the vestibular epithelium. This potential can be awakened under pathological conditions and become a source of pathologies in the vestibular area.
Trvalý link: http://hdl.handle.net/11104/0268177