Altered thyroid status affects myocardial expression of connexin-43 and susceptibility of rat heart to malignant arrhythmias that can be partially normalized by red palm oil intake

0474132 - FGÚ 2018 RIV DE eng J - Článek v odborném periodiku
Szeiffová Bačová, B. - Vinczenzová, C. - Žurmanová, J. - Kašparová, Dita - Knezl, V. - Egan Beňová, T. - Pavelka, Stanislav - Soukup, Tomáš - Tribulová, N.
Altered thyroid status affects myocardial expression of connexin-43 and susceptibility of rat heart to malignant arrhythmias that can be partially normalized by red palm oil intake.
Histochemistry and Cell Biology. Roč. 147, č. 1 (2017), s. 63-73. ISSN 0948-6143. E-ISSN 1432-119X
Grant CEP: GA MŠMT(CZ) LH15279; GA MŠMT(CZ) 7AMB14SK123
Grant ostatní: AV ČR(CZ) SAV-15-03
Program: Bilaterální spolupráce
Institucionální podpora: RVO:67985823
Klíčová slova: thyroid hormones * cardiac arrhythmias * connexin-43 * PKC * red palm oil
Obor OECD: Physiology (including cytology)
Impakt faktor: 2.164, rok: 2017

We aimed to study the impact of altered thyroid status on myocardial expression of electrical coupling protein connexin-43 (Cx43), the susceptibility of rats to ventricular fibrillation (VF) and the effects of antioxidant-rich red palm oil (RPO). We found that function of the heart was partially normalized by RPO intake, which also enhanced myocardial Cx43 and PKC-epsilon expression as well as increased VF threshold in hyperthyroid male rats. From the results obtained we conclude that there is an inverse relationship between myocardial expression of Cx43, including its functional phosphorylated forms, and susceptibility of male rat hearts to VF in condition of altered thyroid status. RPO intake partly ameliorated adverse changes caused by excess of thyroid hormones.
Trvalý link: http://hdl.handle.net/11104/0271244