Počet záznamů: 1
Bioactive metabolites of docosahexaenoic acid
- 1.0474742 - FGÚ 2018 RIV FR eng J - Článek v odborném periodiku
Kuda, Ondřej
Bioactive metabolites of docosahexaenoic acid.
Biochimie. Roč. 136, May (2017), s. 12-20. ISSN 0300-9084. E-ISSN 1638-6183
Grant CEP: GA ČR(CZ) GA16-04859S; GA MZd(CZ) NV16-29182A
Institucionální podpora: RVO:67985823
Klíčová slova: DHA * specialized proresolving mediators * FAHFA * DHEA * N-acyl amides * omega-3 PUFA
Obor OECD: Endocrinology and metabolism (including diabetes, hormones)
Impakt faktor: 3.188, rok: 2017
Docosahexaenoic acid (DHA) is an essential fatty acid that is recognized as a beneficial dietary constituent and as a source of the anti-inflammatory specialized proresolving mediators (SPM): resolvins, protectins and maresins. Apart from SPMs, other metabolites of DHA also exert potent biological effects. This article summarizes current knowledge on the metabolic pathways involved in generation of DHA metabolites. Over 70 biologically active metabolites have been described, but are often discussed separately within specific research areas. This review follows DHA metabolism and attempts to integrate the diverse DHA metabolites emphasizing those with identified biological effects. DHA metabolites could be divided into DHA-derived SPMs, DHA epoxides, electrophilic oxo-derivatives (EFOX) of DHA, neuroprostanes, ethanolamines, acylglycerols, docosahexaenoyl amides of amino acids or neurotransmitters, and branched DHA esters of hydroxy fatty acids. These bioactive metabolites have pleiotropic effects that include augmenting energy expenditure, stimulating lipid catabolism, modulating the immune response, helping to resolve inflammation, and promoting wound healing and tissue regeneration. As a result they have been shown to exert many beneficial actions: neuroprotection, anti-hypertension, anti-hyperalgesia, anti-arrhythmia, anti-tumorigenesis etc. Given the chemical structure of DHA, the number and geometry of double bonds, and the panel of enzymes metabolizing DHA, it is also likely that novel bioactive derivatives will be identified in the future.
Trvalý link: http://hdl.handle.net/11104/0271711
Počet záznamů: 1