Stimulating autophagy and reducing inclusions in mouse model of Huntington's disease via expression of transcription factor EB (TFEB)

0484446 - ÚŽFG 2018 CZ eng K - Konferenční příspěvek (tuzemská konf.)
Vodička, Petr - Chase, K. - Iulliano, M. - Tousley, A. - Valentine, D. T. - Sapp, E. - Kegel-Gleason, K. B. - Sena-Esteves, M. - Aronin, N. - DiFiglia, M.
Stimulating autophagy and reducing inclusions in mouse model of Huntington's disease via expression of transcription factor EB (TFEB).
The 4th Animal Models of Neurodegenerative Diseases. Liběchov: ÚŽFG AV ČR, v. v. i., 2017, s. 14-15.
[Animal Models of Neurodegenerative Diseases /4./. Liblice (CZ), 22.10.2017-24.10.2017]
Grant CEP: GA MŠMT(CZ) LO1609
Institucionální podpora: RVO:67985904
Klíčová slova: mutant huntingtin
Obor OECD: Genetics and heredity (medical genetics to be 3)

Mutant huntingtin (mHTT) is encoded by the Huntington’s disease (HD) gene and its accumulation in the brain contributes to HD pathogenesis. Reducing mHTT levels through activation of the autophagosome-lysosomal pathway may have therapeutic benefit. Transcription factor EB (TFEB) regulates lysosome biogenesis and autophagy. We introduced cDNA encoding TFEB with an HA tag (TFEB-HA) under the control of neuron specific synapsin 1 promoter into the striatum of 3 month old HDQ175/Q7 mice using adeno-associated virus AAV2/9.
Trvalý link: http://hdl.handle.net/11104/0279609