A New Bis(aquated) High Relaxivity Mn(II) Complex as an Alternative to Gd(III)-Based MRI Contrast Agent

0489993 - ÚOCHB 2019 RIV US eng J - Článek v odborném periodiku
Phukan, B. - Mukherjee, C. - Goswami, U. - Sarmah, Amrit - Mukherjee, S. - Sahoo, S. K. - Moi, S. C.
A New Bis(aquated) High Relaxivity Mn(II) Complex as an Alternative to Gd(III)-Based MRI Contrast Agent.
Inorganic Chemistry. Roč. 57, č. 5 (2018), s. 2631-2638. ISSN 0020-1669. E-ISSN 1520-510X
Institucionální podpora: RVO:61388963
Klíčová slova: nephrogenic systemic fibrosis * Mn2+ complexes * gadolinium complex
Obor OECD: Physical chemistry
Impakt faktor: 4.850, rok: 2018

Disclosed here are a piperazine, a pyridine, and two carboxylate groups containing pentadentate ligand H(2)pmpa and its corresponding water-soluble Mn(II) complex (1). DFT-based structural optimization implied that the complex had pentagonal bipyramidal geometry where the axial positions were occupied by two water molecules, and the equatorial plane was constituted by the ligand ON3O donor set. Thus, a bis(aquated) disc-like Mn(II) complex has been synthesized. The complex showed higher stability compared with Mn(II)-EDTA complex [logK(MnL) = 14.29(3)] and showed a very high r(1) relaxivity value of 5.88 mM(-1) s(-1) at 1.41 T, 25 degrees C, and pH = 7.4. The relaxivity value remained almost unaffected by the pH of the medium in the range of 6-10. Although the presence of 200 equiv of fluoride and bicarbonate anions did not affect the relaxivity value appreciably, an increase in the value was noticed in the presence of phosphate anion due to slow tumbling of the complex. Cell viability measurements, as well as phantom MR images using clinical MRI imager, consolidated the possible candidature of complex 1 as a positive contrast agent.
Trvalý link: http://hdl.handle.net/11104/0284284