Počet záznamů: 1  

Antimicrobial, Cytotoxic, Anti-Inflammatory, and Antioxidant Activity of Culinary Processed Shiitake Medicinal Mushroom (Lentinus edodes, Agaricomycetes) and Its Major Sulfur Sensory-Active Compound-Lenthionine

  1. 1.
    0490717 - MBÚ 2019 RIV US eng J - Článek v odborném periodiku
    Kupcová, K. - Štefanová, I. - Plavcová, Z. - Hošek, J. - Hrouzek, Pavel - Kubec, R.
    Antimicrobial, Cytotoxic, Anti-Inflammatory, and Antioxidant Activity of Culinary Processed Shiitake Medicinal Mushroom (Lentinus edodes, Agaricomycetes) and Its Major Sulfur Sensory-Active Compound-Lenthionine.
    International Journal of Medicinal Mushrooms. Roč. 20, č. 2 (2018), s. 165-175. ISSN 1521-9437. E-ISSN 1940-4344
    Grant CEP: GA MŠMT(CZ) LO1416; GA MŠMT(CZ) ED2.1.00/19.0392
    Institucionální podpora: RVO:61388971
    Klíčová slova: anti-inflammatory activity * antimicrobial activity * antioxidant activity
    Obor OECD: Microbiology
    Impakt faktor: 1.423, rok: 2018

    The antimicrobial, cytotoxic, anti-inflammatory, and antioxidant properties of aqueous extracts of raw and culinary processed shiitake mushrooms were evaluated and compared with those of lenthionine (1,2,3,5,6-pentathiepane), the principal aroma-bearing substance of the shiitake medicinal mushroom (Lentinus edodes). Antimicrobial activity was tested using a panel of 4 strains of bacteria, 2 yeasts, and 2 fungi. Cytotoxic properties were evaluated against 3 cell lines (HepG2, HeLa, PaTu), whereas the anti-inflammatory activity of tested samples was assayed based on their ability to attenuate the secretion of the cytokine tumor necrosis factor-a. Antioxidant activity was measured using in vitro DPPH and ARTS assays. It was found that lenthionine possesses significant antimicrobial properties, it is remarkably effective in inhibiting the growth of yeasts and fungi (minimum inhibitory concentration, 2-8 mu g/mL) and thus is comparable to standard antifungal agents. Lenthionine is also able to decrease significantly the production of tumor necrosis factor-a and thus could be at least partly responsible for the observed anti-inflammatory effect of shiitake. On the other hand, lenthionine does not seem to contribute significantly to the well-known anticancer and antioxidant effects of the mushroom.
    Trvalý link: http://hdl.handle.net/11104/0284900

     
     
Počet záznamů: 1  

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