Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis

0492350 - ÚŽFG 2019 RIV CH eng J - Článek v odborném periodiku
Kalous, Jaroslav - Tětková, Anna - Kubelka, Michal - Šušor, Andrej
Importance of ERK1/2 in Regulation of Protein Translation during Oocyte Meiosis.
International Journal of Molecular Sciences. Roč. 19, č. 3 (2018), č. článku 698. E-ISSN 1422-0067
Grant CEP: GA ČR GA15-22765S; GA MŠMT EF15_003/0000460
Institucionální podpora: RVO:67985904
Klíčová slova: ERK1/2 * MAP kinase * mTOR
Obor OECD: Reproductive biology (medical aspects to be 3)
Impakt faktor: 4.183, rok: 2018

Although the involvement of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway in the regulation of cytostatic factor (CSF) aktivity, as well as in microtubules organization during meiotic maturation of oocytes, has already been described in detail, rather less attention has been paid to the role of ERK1/2 in the regulation of mRNA translation. However, important data on the role of ERK1/2 in translation during oocyte meiosis have been documented. This review focuses on recent findings regarding the regulation of translation and the role of ERK1/2 in this process in the meiotic cycle of mammalian oocytes. The specific role of ERK1/2 in the regulation of mammalian target of rapamycin (mTOR), eukaryotic translation initiation factor 4E (eIF4E) and cytoplasmic polyadenylation element binding protein 1 (CPEB1) activity is addressed along with additional focus on the other key players involved in protein translation.
Trvalý link: http://hdl.handle.net/11104/0285910