Počet záznamů: 1  

Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans

  1. 1.
    0494041 - MBÚ 2019 RIV NL eng J - Článek v odborném periodiku
    Chrenková, V. - Hubka, Vít - Cetkovský, P. - Kouba, M. - Weinbergerová, B. - Lysková, P. - Hornofová, L. - Hubáček, P.
    Proven Invasive Pulmonary Aspergillosis in Stem Cell Transplant Recipient Due to Aspergillus sublatus, a Cryptic Species of A-nidulans.
    Mycopathologia. Roč. 183, č. 2 (2018), s. 423-429. ISSN 0301-486X. E-ISSN 1573-0832
    Grant CEP: GA MŠMT(CZ) ED1.1.00/02.0109
    Institucionální podpora: RVO:61388971
    Klíčová slova: Aspergillus quadrilineatus * Haematopoietic stem cell transplant * Invasive aspergillosis
    Obor OECD: Microbiology
    Impakt faktor: 2.278, rok: 2018

    Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Autopsy samples revealed histopathological evidence of fungal hyphae and an unusual Aspergillus nidulans-like species was isolated in pure culture. More precise identification was achieved by using scanning electron microscopy of ascospores and sequencing of calmodulin gene, and the isolate was subsequently re-identified as A. sublatus (section Nidulantes) and showed good in vitro susceptibility against all classes of antifungals. Commonly used ITS rDNA region and beta-tubulin gene fail to discriminate A. sublatus from related pathogenic species, especially A. quadrilineatus and A. nidulans. Although this is the first case of proven IPA attributed to A. sublatus, we demonstrated that at least some previously reported infections due to A. quadrilineatus were probably caused by this cryptic species.
    Trvalý link: http://hdl.handle.net/11104/0287283

     
     
Počet záznamů: 1  

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