Beyond the classical thermodynamic contributions to hydrogen atom abstraction reactivity

0498526 - ÚOCHB 2019 RIV US eng J - Článek v odborném periodiku
Bím, Daniel - Maldonado-Domínguez, M. - Rulíšek, Lubomír - Srnec, M.
Beyond the classical thermodynamic contributions to hydrogen atom abstraction reactivity.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 115, č. 44 (2018), E10287-E10294. ISSN 0027-8424. E-ISSN 1091-6490
Institucionální podpora: RVO:61388963
Klíčová slova: reduction potential * acidity constant * reorganization energy * asynchronicity factor * hydrogen atom transfer
Obor OECD: Physical chemistry
Impakt faktor: 9.580, rok: 2018

Hydrogen atom abstraction (HAA) reactions are cornerstones of chemistry. Various (metallo)enzymes performing the HAA catalysis evolved in nature and inspired the rational development of multiple synthetic catalysts. Still, the factors determining their catalytic efficiency are not fully understood. Herein, we define the simple thermodynamic factor eta by employing two thermodynamic cycles: one for an oxidant (catalyst), along with its reduced, protonated, and hydrogenated form, and one for the substrate, along with its oxidized, deprotonated, and dehydrogenated form. It is demonstrated that eta reflects the propensity of the substrate and catalyst for (a)synchronicity in concerted H+/e(-) transfers. As such, it significantly contributes to the activation energies of the HAA reactions, in addition to a classical thermodynamic (Bell-EvansPolanyi) effect. In an attempt to understand the physicochemical interpretation of eta, we discovered an elegant link between vertical bar eta vertical bar and reorganization energy lambda, from Marcus theory. We discovered computationally that for a homologous set of HAA reactions, lambda, reaches its maximum for the lowest eta, which then corresponds to the most synchronous HAA mechanism. This immediately implies that among HAA processes with the same reaction free energy, Delta G(0), the highest barrier (Delta G not equal) is expected for the most synchronous proton-coupled electron (i.e., hydrogen) transfer. As proof of concept, redox and acidobasic properties of nonheme Fe-IV O complexes are correlated with activation free energies for HAA from C-H and O-H bonds. We believe that the reported findings may represent a powerful concept in designing new HAA catalysts.
Trvalý link: http://hdl.handle.net/11104/0291124