Pregnanolone derivatives substituted in 3alpha-position with the cationic group, usage and pharmaceutical preparation involving them

0500216 - ÚOCHB 2019 RIV eng P - Patentový dokument
Chodounská, Hana - Kapras, Vojtěch - Vyklický ml., Ladislav - Borovská, Jiřina - Vyklický, Vojtěch - Valeš, Karel - Stuchlík, Aleš - Rambousek, Lukáš
Pregnanolone derivatives substituted in 3alpha-position with the cationic group, usage and pharmaceutical preparation involving them.
2018. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. - Fyziologický ústav AV ČR, v. v. i. Datum udělení patentu: 18.04.2018. Číslo patentu: EP2675821
Institucionální podpora: RVO:61388963 ; RVO:67985823
Klíčová slova: pregnanolone derivatives * CNS * neuroactive steroids * neuroprotectives
Obor OECD: Organic chemistry
https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20180418&DB=&locale=en_EP&CC=EP&NR=2675821B1&KC=B1&ND=4#

The presented invention applies to pregnanolone derivatives, substituted in 3 alpha-position with the cationic group, of general formula I, the method of the production of these compounds and their utilization for treatment of neuropsychiatric disorders related to imbalance of glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post traumatic stress dissorder, and other diseases related to stress, anxiety, schizophrenia, and psychotic disorders, pain, addictions, multiple sclerosis, epilepsy, and gliomas. The object of invention is also the use of compounds of general formula I for production of veterinary and human pharmaceutical preparation for treatment of above mentioned diseases and for production of pharmaceutical preparations containing these compounds.
Trvalý link: http://hdl.handle.net/11104/0293002