Počet záznamů: 1
Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level
- 1.0503153 - BTÚ 2019 RIV eng P - Patentový dokument
Neužil, Jiří - Werner, L. - Štursa, J.
Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level.
2018. Vlastník: J. Neužil, Biotechnologický ústav AV ČR, v. v. i., Smart Brain s.r.o., KKCG AG. Datum udělení patentu: 23.03.2018. Číslo patentu: NZ713589
Institucionální podpora: RVO:86652036
Klíčová slova: Mitochondrial targeting * Anticancer * Respiration
Obor OECD: Biochemistry and molecular biology
https://app.iponz.govt.nz/app/Extra/IP/Mutual/Browse.aspx?sid=636808585975018936
The subject of the invention are new mitochondrially targeted E/Z isomers of aliphatic triphenylphosphonium derivatives
of tamoxifen where the aliphatic chain is alkyl or alkenyl, and their corresponding tertiary amine salts and/or their mixture
(MitoTAX). Alkyl triphenylphosphonium derivatives oftamoxifen have the general formula (I), where n=8 to 12 and where Z is selected
from the group of organic salts or inorganic salts. Alkenyl triphenylphosphonium derivatives of tamoxifen have the general
formula IA, where n = 6 to l 0 and where Z has the above mentioned meaning. These compounds are applicable for the treatment of
neoplastic disease, especially those with high HER2 protein levels. The drug for the treatment of neoplastic diseases according to the
invention contains at least one E/Z isomer of aliphatic triphenylphosphonium derivatives of tamoxifen of the general formula (I)
and/or IA or their corresponding salts of tertiary amine.
Trvalý link: http://hdl.handle.net/11104/0294968
Počet záznamů: 1