Adaptive integrate-and-fire model reproduces the dynamics of olfactory receptor neuron responses in a moth

0509159 - FGÚ 2020 RIV GB eng J - Článek v odborném periodiku
Leváková, Marie - Košťál, Lubomír - Monsempés, Ch. - Lucas, P. - Kobayashi, R.
Adaptive integrate-and-fire model reproduces the dynamics of olfactory receptor neuron responses in a moth.
Journal of the Royal Society Interface. Roč. 16, č. 157 (2019), č. článku 20190246. ISSN 1742-5689. E-ISSN 1742-5662
Grant CEP: GA ČR(CZ) GA17-06943S; GA MŠMT(CZ) 7AMB17FR059
Institucionální podpora: RVO:67985823
Klíčová slova: adaptive threshold * olfactory receptor neuron * integrate-and-fire model
Obor OECD: Applied mathematics
Impakt faktor: 3.748, rok: 2019
Způsob publikování: Open access
https://doi.org/10.1098/rsif.2019.0246

In order to understand how olfactory stimuli are encoded and processed in the brain, it is important to build a computational model for olfactory receptor neurons (ORNs). Here, we present a simple and reliable mathematical model of a moth ORN generating spikes. The model incorporates a simplified description of the chemical kinetics leading to olfactory receptor activation and action potential generation. We show that an adaptive spike threshold regulated by prior spike history is an effective mechanism for reproducing the typical phasic–tonic time course of ORN responses. Our model reproduces the response dynamics of individual neurons to a fluctuating stimulus that approximates odorant fluctuations in nature. The parameters of the spike threshold are essential for reproducing the response heterogeneity in ORNs. The model provides a valuable tool for efficient simulations of olfactory circuits.
Trvalý link: http://hdl.handle.net/11104/0299942