Počet záznamů: 1
Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis
- 1.0510897 - BFÚ 2020 RIV US eng J - Článek v odborném periodiku
Beauvarlet, J. - Mergny, Jean-Louis - Djavaheri-Mergny, M.
Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis.
Molecular & Cellular Oncology. Roč. 6, č. 4 (2019), č. článku e1604047. ISSN 2372-3556
Grant CEP: GA MŠMT EF15_003/0000477
Institucionální podpora: RVO:68081707
Klíčová slova: autophagy * damage * Cancer therapy * G-quadruplex * autophagy
Obor OECD: Oncology
Způsob publikování: Omezený přístup
https://www.tandfonline.com/doi/full/10.1080/23723556.2019.1604047
G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.
Trvalý link: http://hdl.handle.net/11104/0301264
Počet záznamů: 1