Amphiphilic compounds with neuroprotective properties

0519503 - ÚOCHB 2020 RIV eng P - Patentový dokument
Kudová, Eva - Chodounská, Hana - Kapras, Vojtěch - Vyklický ml., Ladislav - Valeš, Karel - Jahn, Ullrich
Amphiphilic compounds with neuroprotective properties.
2019. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. - Fyziologický ústav AV ČR, v. v. i. Datum udělení patentu: 02.10.2019. Číslo patentu: EP3186267
Grant CEP: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GBP304/12/G069
Institucionální podpora: RVO:61388963 ; RVO:67985823
Klíčová slova: steroid * NMDA receptor * neuroprotective
Obor OECD: Organic chemistry; Pharmacology and pharmacy (FGU-C)
https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20191002&DB=&locale=en_EP&CC=EP&NR=3186267B1&KC=B1&ND=6#

The present invention provides amphiphilic compounds with a tetradecahydrophenanthrene skeleton of formula (I), wherein R1-R5 are as defined herein, and their enantiomers, exhibiting neuroprotective effects, for use as medicaments for treating neuropsychiatric disorders associated with an imbalance in glutamatergic neurotransmitter system, such as ischemic damage of CNS, neurodegenerative changes and disorders of CNS, affective disorders, depression, post-traumatic stress disorder and diseases related to stress, anxiety, schizophrenia and psychotic disorders, pain , addiction, multiple sclerosis, epilepsy, glioma, and a pharmaceutical composition containing said compound.
Trvalý link: http://hdl.handle.net/11104/0304530