Počet záznamů: 1
Cyclodextrin-based transporter of nucleoside triphosphate transporter across the cell membrane, its preparation and use
- 1.0519507 - ÚOCHB 2020 RIV eng P - Patentový dokument
Kraus, Tomáš - Zawada, Zbigniew
Cyclodextrin-based transporter of nucleoside triphosphate transporter across the cell membrane, its preparation and use.
2019. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. Datum udělení patentu: 29.05.2019. Číslo patentu: EP3402839
Grant CEP: GA ČR(CZ) GA17-14791S
Institucionální podpora: RVO:61388963
Klíčová slova: transmembrane transport * anion transporters * DNA labelling
Obor OECD: Organic chemistry
https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=EP&NR=3402839B1&KC=B1&FT=D&ND=4&date=20190529&DB=&locale=en_EP#
Compounds of general formula 6 and 13 where X is -NH-C(NH2)=N+H2 or -N+H3, Y is a linear oligomer consisting of arginine units terminated with an aminodimethylenamide unit (-Arg)n-NH-(CH2)2-NH2, where n = 6-10, or arginine-aminocaproic units (-Arg-Aca)n- NH2, where n = 6 to 10, A- = CF3COO- or C1- and m = 1-2. Preparation and use of compounds of general formula 6 and 13 as carriers of nucleoside triphosphates across the cell membranes for the purpose of incorporation of modified nucleoside triphosphates into the cellular DNA or RNA. Use of compounds of general formula 6 and 13 as carriers of nucleoside triphosphates across the cell membrane for the purpose of determining the virostatic activities of modified nucleoside triphosphates. Use of compounds of general formula 6 and 13 as carriers of modified nucleoside triphosphates across the cell membrane for the purpose of determining cell proliferation and S phase of the cell cycle.
Trvalý link: http://hdl.handle.net/11104/0304616
Počet záznamů: 1