Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation

0535242 - MBÚ 2021 RIV CH eng J - Článek v odborném periodiku
Ahmad, Jawid Nazir - Šebo, Peter
Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation.
Frontiers in Immunology. Roč. 11, SEP 11 2020 (2020), č. článku 2181. ISSN 1664-3224. E-ISSN 1664-3224
Grant CEP: GA ČR(CZ) GX19-27630X
Institucionální podpora: RVO:61388971
Klíčová slova: dedifferentiation * Bordetella pertussis * adenylate cyclase toxin
Obor OECD: Immunology
Impakt faktor: 7.561, rok: 2020
Způsob publikování: Open access
https://www.frontiersin.org/articles/10.3389/fimmu.2020.02181/full

Circulating inflammatory monocytes are attracted to infected mucosa and differentiate into macrophage or dendritic cells endowed with enhanced bactericidal and antigen presenting capacities. In this brief Perspective we discuss the newly emerging insight into how the cAMP signaling capacity ofBordetella pertussisadenylate cyclase toxin manipulates the differentiation of monocytes and trigger dedifferentiation of the alveolar macrophages to facilitate bacterial colonization of human airways.
Trvalý link: http://hdl.handle.net/11104/0313329