Mechanochemically induced polymorphic transformations of sofosbuvir

0537826 - FZÚ 2021 RIV US eng J - Článek v odborném periodiku
Chatziadi, A. - Skořepová, Eliška - Rohlíček, Jan - Dušek, Michal - Ridvan, L. - Šoós, M.
Mechanochemically induced polymorphic transformations of sofosbuvir.
Crystal Growth & Design. Roč. 20, č. 1 (2020), s. 139-147. ISSN 1528-7483. E-ISSN 1528-7505
Grant CEP: GA TA ČR TJ02000256
Institucionální podpora: RVO:68378271
Klíčová slova: crystal-structures * coordination * polymorphism * vibration ball milling * hepatitis treatment
Obor OECD: Condensed matter physics (including formerly solid state physics, supercond.)
Impakt faktor: 4.076, rok: 2020
Způsob publikování: Omezený přístup
https://doi.org/10.1021/acs.cgd.9b00922

In this study, vibrational ball milling was used to investigate the polymorphic transformations of sofosbuvir, a drug that is used for the treatment of hepatitis C, under different experimental conditions. We observed that by changing the type of liquid additive, the starting form 1 after 30 min of milling transformed mainly to an amorphous phase or form A, which is the most thermodynamically stable form at room temperature. Furthermore, by exploring different time periods of milling we discovered that, depending on the nature of the liquid additive, the transformation toward the most stable form can occur through different intermediate forms.

Trvalý link: http://hdl.handle.net/11104/0315661