Natural pseurotins and analogs thereof inhibit activation of B-cells and differentiation into the plasma cells

0540508 - BFÚ 2021 RIV DE eng J - Článek v odborném periodiku
Vašíček, Ondřej - Fedr, Radek - Skoroplyas, Svitlana - Chalupa, D. - Sklenář, M. - Tharra, P. R. - Svenda, J. - Kubala, Lukáš
Natural pseurotins and analogs thereof inhibit activation of B-cells and differentiation into the plasma cells.
Phytomedicine. Roč. 69, APR 2020 (2020), č. článku 153194. ISSN 0944-7113. E-ISSN 1618-095X
Grant CEP: GA ČR(CZ) GA17-18858S
Institucionální podpora: RVO:68081707
Klíčová slova: pseudeurotium-ovalis stolk * cd40 ligand * ige * proliferation
Obor OECD: Pharmacology and pharmacy
Impakt faktor: 5.340, rok: 2020
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S0944711320300271?via%3Dihub

Background: The frequency of allergic diseases is constantly rising. Dysregulated production of isotype E immunoglobulins is one of the key factors behind allergic reactions and its modulation is therefore an important target for pharmacological intervention. Natural products of the pseurotin family were reported to be inhibitors of IgE production in B-cells. Mechanistic details underlying these effects are however not well understood.
Trvalý link: http://hdl.handle.net/11104/0318133