Long non-coding RNAs and splicing

0544114 - ÚMG 2022 RIV GB eng J - Článek v odborném periodiku
Staněk, David
Long non-coding RNAs and splicing.
Essays in Biochemistry. Roč. 65, č. 4 (2021), s. 723-729. ISSN 0071-1365. E-ISSN 1744-1358
Grant CEP: GA ČR GA20-04099S
Institucionální podpora: RVO:68378050
Klíčová slova: SR proteins * large intervening non-coding RNA * spliceosomes * splicing
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 7.258, rok: 2021
Způsob publikování: Omezený přístup
https://portlandpress.com/essaysbiochem/article-abstract/doi/10.1042/EBC20200087/228261/Long-non-coding-RNAs-and-splicing?redirectedFrom=fulltext

In this review I focus on the role of splicing in long non-coding RNA (lncRNA) life. First, I summarize differences between the splicing efficiency of protein-coding genes and lncRNAs and discuss why non-coding RNAs are spliced less efficiently. In the second half of the review, I speculate why splice sites are the most conserved sequences in lncRNAs and what additional roles could splicing play in lncRNA metabolism. I discuss the hypothesis that the splicing machinery can, besides its dominant role in intron removal and exon joining, protect cells from undesired transcripts.
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
Trvalý link: http://hdl.handle.net/11104/0321165