The role of interictal discharges in ictogenesis-A dynamical perspective

0544569 - FGÚ 2022 RIV US eng J - Článek v odborném periodiku
Chvojka, Jan - Kudláček, Jan - Chang, W.-Ch. - Novák, O. - Tomáška, F. - Otáhal, Jakub - Jefferys, J. G. R. - Jiruška, Přemysl
The role of interictal discharges in ictogenesis-A dynamical perspective.
Epilepsy and Behavior. Roč. 121, Part B Aug (2021), č. článku 106591. ISSN 1525-5050. E-ISSN 1525-5069
Grant CEP: GA MZd(CZ) NV17-28427A
Institucionální podpora: RVO:67985823
Klíčová slova: interictal epileptiform discharge * epilepsy * seizures * dynamics * transition to seizure * critical slowing
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 3.337, rok: 2021
Způsob publikování: Omezený přístup
https://doi.org/10.1016/j.yebeh.2019.106591

Interictal epileptiform discharge (IED) is a traditional hallmark of epileptic tissue that is generated by the synchronous activity of a population of neurons. Interictal epileptiform discharges represent a heterogeneous group of pathological activities that differ in shape, duration, spatiotemporal distribution, underlying cellular and network mechanisms, and their relationship to seizure genesis. The exact role of IEDs in epilepsy is still not well understood, and there remains a persistent dichotomy about the impact on IEDs on seizures. Proseizure, antiseizure, and no impact on ictogenesis have all been described in previous studies. In this article, we review the existing knowledge on the role of interictal discharges in seizure genesis, and we discuss how dynamical approaches to ictogenesis can explain the existing dichotomy about the multifaceted role of IEDs in ictogenesis.
Trvalý link: http://hdl.handle.net/11104/0321417