Glass ionomer cement modified by a imidazolium salt: adding antifungal properties to a biomaterial

0544228 - ÚMCH 2022 RIV BR eng J - Článek v odborném periodiku
Ehrhardt, A. - Mandelli, J. Z. A. - Bérgamo, V. - Lopes, W. - Donato, Ricardo Keitel - Zanette, R. A. - Fuentefria, A. M.
Glass ionomer cement modified by a imidazolium salt: adding antifungal properties to a biomaterial.
Brazilian Journal of Microbiology. Roč. 52, č. 3 (2021), s. 1347-1352. ISSN 1517-8382. E-ISSN 1678-4405
Institucionální podpora: RVO:61389013
Klíčová slova: antibiofilm activity * dental material * Candida spp
Obor OECD: Polymer science
Impakt faktor: 2.214, rok: 2021
Způsob publikování: Omezený přístup
https://link.springer.com/article/10.1007%2Fs42770-021-00511-5

We present the structural modification of a commercially available glass ionomer cement by inserting the imidazolium salt 1-n-hexadecyl-3-methylimidazolium chloride (C16MImCl), composing a new biomaterial with antifungal biofilm activity. Test specimens were prepared using a commercial glass ionomer cement to which 10 ppm of cetylpyridinium chloride (reference ionic antifungal agent) or C16MImCl were added. The feasibility and hypoallergenicity of the new biomaterial were assessed by microhardness plastic deformation and chorioallantoic membrane assays. Colony counting and scanning electron microscopy were used to evaluate the modified specimens’ antibiofilm activity against three multidrug-resistant Candida species. The modified glass ionomer cement presented a strong antibiofilm activity against Candida spp., without losing its original micromechanical and hypoallergenic properties, rendering it a promising candidate for further application in dentistry.
Trvalý link: http://hdl.handle.net/11104/0321937