Strongyloides genotyping: a review of methods and application in public health and population genetics

0548740 - ÚBO 2022 RIV AU eng J - Článek v odborném periodiku
Bradbury, R. S. - Pafčo, Barbora - Nosková, E. - Hasegawa, H.
Strongyloides genotyping: a review of methods and application in public health and population genetics.
International Journal for Parasitology. Roč. 51, 13-14 (2021), s. 1153-1166. ISSN 0020-7519. E-ISSN 1879-0135
Grant ostatní: AV ČR(CZ) JSPS-19-17
Program: Bilaterální spolupráce
Institucionální podpora: RVO:68081766
Klíčová slova: Epidemiology * Genome * Genotyping * Strongyloides * Strongyloides fuelleborni * Strongyloides stercoralis * Strongyloidiasis
Obor OECD: Genetics and heredity (medical genetics to be 3)
Impakt faktor: 4.330, rok: 2021
Způsob publikování: Omezený přístup
https://www.sciencedirect.com/science/article/pii/S0020751921002976?via%3Dihub

Strongyloidiasis represents a major medical and veterinary helminthic disease. Human infection is caused by Strongyloides stercoralis, Strongyloides fuelleborni fuelleborni and Strongyloides fuelleborni kellyi, with S. stercoralis accounting for the majority of cases. Strongyloides f. fuelleborni likely represents a zoonosis acquired from non-human primates (NHPs), while no animal reservoir for S. f. kellyi infection has been found. Whether S. stercoralis represents a zoonosis acquired from dogs and cats remains unanswered. Over the past two decades various tools have been applied to genotype Strongyloides spp. The most commonly sequenced markers have been the hyper-variable regions I and IV of the 18S rRNA gene and selected portions of the cytochrome c oxidase subunit I gene. These markers have been sequenced and compared in Strongyloides from multiple hosts and geographical regions. More recently, a machine learning algorithm multi-locus sequence typing approach has been applied using these markers, while others have applied whole genome sequencing. Genotyping of Strongyloides from dogs, cats, NHPs and humans has identified that S. stercoralis likely originated in dogs and adapted to human hosts. It has also been demonstrated that S. stercoralis is distinct from S. f. fuelleborni and S. f. kellyi. Two distinct genetic clades of S. stercoralis exist, one restricted to dogs and another infecting humans, NHPs, dogs and cats. Genotyping of S. f. fuelleborni has identified two separate clades, one associated with African isolates and another Indochinese peninsular clade. This review summarises the history and development of genotyping tools for Strongyloides spp. It describes the findings of major studies to date in the context of the epidemiology and evolutionary biology of these helminths, with a specific focus on human-infecting species.
Trvalý link: http://hdl.handle.net/11104/0324787