Non-Coding RNAs as Biomarkers of Tumor Progression and Metastatic Spread in Epithelial Ovarian Cancer

0556280 - ÚEM 2022 RIV CH eng J - Článek v odborném periodiku
Šeborová, K. - Václavíková, R. - Rob, L. - Souček, P. - Vodička, Pavel
Non-Coding RNAs as Biomarkers of Tumor Progression and Metastatic Spread in Epithelial Ovarian Cancer.
Cancers (Basel). Roč. 13, č. 8 (2021), č. článku 1839. E-ISSN 2072-6694
Grant CEP: GA ČR(CZ) GA19-10543S
Institucionální podpora: RVO:68378041
Klíčová slova: ovarian cancer * progression * metastasis * ncRNA * miRNA * lncRNA * biomarkers * epigenetics
Obor OECD: Genetics and heredity (medical genetics to be 3)
Impakt faktor: 6.575, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/2072-6694/13/8/1839

Despite advances in cancer research in recent years, efficient predictive biomarkers of tumor progression and metastatic spread for ovarian cancer are still missing. Therefore, we critically address recent findings in the field of non-coding RNAs (microRNAs and long non-coding RNAs) and DNA methylation in ovarian cancer patients as promising novel biomarkers of ovarian cancer progression.

Ovarian cancer is one of the most common causes of death among gynecological malignancies. Molecular changes occurring in the primary tumor lead to metastatic spread into the peritoneum and the formation of distant metastases. Identification of these changes helps to reveal the nature of metastases development and decipher early biomarkers of prognosis and disease progression. Comparing differences in gene expression profiles between primary tumors and metastases, together with disclosing their epigenetic regulation, provides interesting associations with progression and metastasizing. Regulatory elements from the non-coding RNA families such as microRNAs and long non-coding RNAs seem to participate in these processes and represent potential molecular biomarkers of patient prognosis. Progress in therapy individualization and its proper targeting also rely upon a better understanding of interactions among the above-listed factors. This review aims to summarize currently available findings of microRNAs and long non-coding RNAs linked with tumor progression and metastatic process in ovarian cancer. These biomolecules provide promising tools for monitoring the patient's response to treatment, and further they serve as potential therapeutic targets of this deadly disease.
Trvalý link: http://hdl.handle.net/11104/0330566