Structural Understanding of SARS-CoV-2 Drug Targets, Active Site Contour Map Analysis and COVID-19 Therapeutics

0557947 - ÚOCHB 2023 RIV AE eng J - Článek v odborném periodiku
Selvaraj, C. - Dinesh, Dhurvas Chandrasekaran - Krafčíková, Petra - Bouřa, Evžen - Aarthy, M. - Pravin, M. A. - Singh, S. K.
Structural Understanding of SARS-CoV-2 Drug Targets, Active Site Contour Map Analysis and COVID-19 Therapeutics.
Current Molecular Pharmacology. Roč. 15, č. 2 (2022), s. 418-433. ISSN 1874-4672. E-ISSN 1874-4702
Grant CEP: GA MŠMT(CZ) EF16_019/0000729
Institucionální podpora: RVO:61388963
Klíčová slova: SARS-CoV-2 * COVID-19 * repurposing * FDA * drug targets * antivirales * active site * contour maps * medicinal plants * phytochemicals * TCM * natural products
Obor OECD: Virology
Impakt faktor: 2.7, rok: 2022
Způsob publikování: Omezený přístup
https://doi.org/10.2174/1874467214666210906125959

The pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is responsible for multiple worldwide lockdowns, an economic crisis, and a substantial increase in hospitalizations for viral pneumonia along with respiratory failure and multiorgan dys-functions. Recently, the first few vaccines were approved by World Health Organization (WHO) and can eventually save millions of lives. Even though, few drugs are used in emergency like Remdesivir and several other repurposed drugs, still there is no approved drug for COVID-19. The coronaviral encoded proteins involved in host-cell entry, replication, and host-cell invading mechanism are potential therapeutic targets. This perspective review provides the molecular overview of SARS-CoV-2 life cycle for summarizing potential drug targets, structural insights, active site contour map analyses of those selected SARS-CoV-2 protein targets for drug discovery, immunology, and pathogenesis.
Trvalý link: http://hdl.handle.net/11104/0331831