- Author
-
J. Martens
G. Berden
R.E. van Outersterp
L.A.J. Kluijtmans
U.F. Engelke
C.D.M. van Karnebeek
R.A. Wevers
J. Oomens - Date
- 13-6-2017
- Title
- Molecular identification in metabolomics using infrared ion spectroscopy
- Journal
- Scientific Reports
- Volume
- 7
- Article number
- 3363
- Number of pages
- 5
- Document type
- Article
- Faculty
- Faculty of Science (FNWI)
- Institute
- Van 't Hoff Institute for Molecular Sciences (HIMS)
- Abstract
-
Small molecule identification is a continually expanding field of research and represents the core challenge in various areas of (bio) analytical science, including metabolomics. Here, we unequivocally differentiate enantiomeric N-acetylhexosamines in body fluids using infrared ion spectroscopy, providing orthogonal identification of molecular structure unavailable by standard liquid chromatography/high-resolution tandem mass spectrometry. These results illustrate the potential of infrared ion spectroscopy for the identification of small molecules from complex mixtures.
- URL
- go to publisher's site
- Language
- English
- Note
- With supplementary file
- Persistent Identifier
- https://hdl.handle.net/11245.1/6bfa7fb0-b626-4649-9244-33e02068db31
- Downloads
-
Molecular(Final published version)
Molecular supplement(Other version)
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