- Author
-
M. Nagasawa
- Title
- Development of human plasmacytoid dendritic cells and innate lymphoid cells
- Supervisors
-
H. Spits
- Co-supervisors
- Award date
- 7 December 2018
- Number of pages
- 249
- ISBN
- 9789090312224
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Innate immune cells play crucial role in the front line of defense against pathogens and harmful substances to protect the human body. One particular subtype are the innate lymphocytes which are characterized by an absence of rearranged antigen specific receptors. Innate lymphocytes have the ability to directly eliminate infected cells and to efficiently coordinate the advanced immune response during infections. In steady state innate lymphocytes are important for the immune tolerance, immune surveillance, maintenance and repair of damaged tissues. Dysregulation of their functions leads to chronic inflammation, autoimmune disease as well as cancer. It is therefore important to understand the essential factors involved in innate lymphocyte development and functionality. Ultimately this will provide clues on how to treat or prevent the aforementioned diseases. In this thesis we described the transcription factors involved in the development of human innate lymphocytes, namely natural killer (NK) cells, innate lymphoid cells (ILCs) and, plasmacytoid dendritic cells (pDCs). Furthermore, the cytokines that control ILCs plasticity are investigated.
- Persistent Identifier
- https://hdl.handle.net/11245.1/f2f9bdb5-57d0-469c-8dc4-73614b68d4ec
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: General introduction
Chapter 2: Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B
Chapter 3: Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development
Chapter 4: Human CD5+ innate lymphoid cells are functionally immature and their development from CD34+ progenitor cells is regulated by Id2
Chapter 5: KLRG1 and NKp46 expression segregate CD117+ human innate lymphoid cells into committed ILC2 and ILC3 precursors
Chapter 6: IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs
Chapter 7: Isolation of human innate lymphoid cells
Chapter 8: General discussion
Summary; Samenvatting; List of authors and affliations; Portfolio; List of publications; Curriculum vitae; Acknowledgement
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