- Author
-
A. Dubin
- Title
- The relationship of CO2 metabolism to tissue perfusion, microcirculation, and treatment response in shock and sepsis
- Supervisors
-
C. Ince
- Award date
- 19 April 2011
- Number of pages
- 246
- ISBN
- 9789490371753
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Arnaldo Dubin belicht de relatie tussen het CO2- of koolstofdioxidemetabolisme, weefselperfusie door microcirculatie en het effect van behandeling op shock en sepsis. Het monitoren van CO2 in weefsels kan waardevolle informatie verschaffen over de circulatie in het lichaam en de weefseldoorbloeding. Het monitoren van de CO2-concentratie in het bloed aan het einde van de uitademing is een non-invasief alternatief voor het meten van het hartminuutvolume (de hoeveelheid bloed die het hart per minuut rondpompt). Daarnaast geeft het meten van weefsel- CO2een indicatie van de microcirculaire doorbloeding.
- Persistent Identifier
- https://hdl.handle.net/11245/1.366159
- Downloads
-
Thesis
Cover
Title pages
Contents
Introduction: Background & outline
Chapter 1: End-tidal CO2 pressure in the monitoring of cardiac output during canine hemorrhagic shock
Chapter 2: End-tidal CO2 pressure determinants during hemorrhagic shock
Chapter 3: Effects of hemorrhage on gastrointestinal oxygenation
Chapter 4: Intramucosal-arterial PCO2 gap fails to reflect intestinal dysoxia in hypoxic hypoxia
Chapter 5: Intramucosal-arterial PCO2 gradient does not reflect intestinal dysoxia in anemic hypoxia
Chapter 6: Urinary bladder partial carbon dioxide tension during hemorrhagic shock and reperfusion: an observational study
Chapter 7: Increased blood flow prevents intramucosal acidosis in sheep endotoxemia: a controlled study
Chapter 8: Effects of levosimendan in normodynamic endotoxaemia: a controlled experimental study
Chapter 9: Effects of levosimendan and dobutamine in experimental acute endotoxemia: a preliminary controlled study
Chapter 10: Persistent villi hypoperfusion explains intramucosal acidosis in sheep endotoxemia
Chapter 11: Determinants of tissue PCO2 in shock and sepsis: relationship to the microcirculation
Chapter 12: Systemic and microcirculatory responses to progressive hemorrhage
Chapter 13: Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study
Chapter 14: Comparison of 6% hydroxyethyl starch 130/0.4 and saline solution for resuscitation of the microcirculation during the early goal-directed therapy of septic patients
Summary and conclusions
Samenvatting and conclusies
Acknowledgments
Curriculum vitae
List of publications
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