- Author
-
H.M. Horlings
- Title
- Improved classification of breast cancer by analysis of genetic alterations and gene expression profiling
- Supervisors
-
M.J. van de Vijver
- Award date
- 1 June 2011
- Number of pages
- 191
- ISBN
- 9789077713921
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
Doel van het onderzoek was betere classificatie van borsttumoren. Hugo Horlings analyseerde genetische veranderingen, zoals het aantal DNA-kopieën of het voorkomen van bepaalde mutaties, en genexpressieprofielen. Normaal borstweefsel onderscheidt zich van invasieve tumoren door verhoogde expressie van microRNA-21. Horlings gebruikte grootschalige RNA-interferentiescreening om genen op te sporen die misschien betrokken zijn bij resistentie tegen Trastuzumab (een middel gebruikt voor de behandeling van borstkanker) en ontdekte een biomarker. Wellicht kan die op termijn gebruikt worden voor identificatie van patiënten die niet reageren op Trastuzumab.
- Persistent Identifier
- https://hdl.handle.net/11245/1.366170
- Downloads
-
Front cover
Title pages
Table of contents
Chapter 1: Introduction and outline of the thesis
Chapter 3: SIRAC: Supervised Identification of Regions of Aberration in aCGH datasets
Chapter 4: Integration of DNA copy number alterations and prognostic gene expression signatures in breast cancer
Chapter 5: ESR1 gene amplification in breast cancer: A common phenomenon?
Chapter 6: Refinement of breast cancer classification by molecular characterization of histological special types
Chapter 7: A functional genetic approach identifies the PI3K pathway as a major determinant of Trastuzumab resistance in breast cancer
Chapter 8: Mutational analysis of PIK3CA and TP53 and their role in breast cancer prognosis
Chapter 9: MicroRNA sequence and expression analysis in breast tumors by deep sequencing
Chapter 10: Discussion and perspectives: Translating the genomic architecture of breast cancer into clinical applications
Chapter 11: Summary of the thesis in English and Dutch
List of publications
Courses / Visiting laboratories
Curriculum vitae
Acknowledgements / Dankwoord
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