- Author
-
L. van der Sluijs Veer
- Title
- Psychological consequences of congenital hypothyroidism: Cognitive, motor and psychosocial functioning
- Supervisors
-
M.A. Grootenhuis
B.F. Last - Co-supervisors
-
T. Vulsma
- Award date
- 7 June 2013
- Number of pages
- 208
- ISBN
- 9789090275505
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
This thesis shows that although the development of children with (permanent) congenital hypothyroidism (CH) is considerably improved by early treatment as a result of neonatal screening, they are still at risk for motor and cognitive problems. This applies especially for children with severe CH. Fine-tuning of treatment and timing does not seem to further improve the positive effect of the screening program. This is probably due to the prenatal hypothyroid state or the thyroid hormone deficiency in early life.
Results of this thesis also show that CH has a negative impact on several aspects of health related quality of life, developmental milestones (Course of Life) and self-esteem. Patients reported more problems with cognitive, motor and psychosocial functioning. This is a source of concern that deserves attention. Therefore awareness of psychological consequences among health care physicians, screening, monitoring and referring of patients to targeted care is of utmost importance. - Note
- Research conducted at: Universiteit van Amsterdam
- Persistent Identifier
- https://hdl.handle.net/11245/1.394651
- Downloads
-
Thesis
Cover
Title pages
Contents
Chapter 1: General introduction
Chapter 2: Intellectual and motor development of young adults with congenital hypothyroidism diagnosed by neonatal screening
Chapter 3: Neonatal screening for congenital hypothyroidism in the Netherlands: Cognitive and motor outcome at 10 years of age
Chapter 4: Evaluation of cognitive and motor development in toddlers with congenital hypothyroidism diagnosed by neonatal screening
Chapter 5: Quality of life, developmental milestones and self-esteem of young adults with congenital hypothyroidism diagnosed by neonatal screening
Chapter 6: Health- related quality of life and self-worth in 10-year old children with congenital hypothyroidism diagnosed by neonatal screening
Chapter 7: Health related quality of life in toddlers with congenital hypothyroidism diagnosed by neonatal screening
Chapter 8: General discussion and future perspectives
Summary of the thesis (English)
Summary of the thesis (Dutch)
Portfolio
Curriculum vitae
Word of thanks (Dutch)
Stellingen
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