- Author
-
A.M. van der Laan
- Title
- Monocytes in ischemic heart disease
- Supervisors
-
J.J. Piek
A.J.G. Horrevoets - Co-supervisors
-
A. Hirsch
N. van Royen - Award date
- 5 July 2013
- Number of pages
- 257
- Publisher
- ‘s-Hertogenbosch: Boxpress
- ISBN
- 9789088916540
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
The link between the immune system and ischemic heart disease has been recognized for years and great improvements have been made in understanding the role of immune cells in the context of infarct healing, atherosclerosis and arteriogenesis, using experimental and in vitro models. However, the role of each cell subset is complex, and considerable differences exist between the reparative responses in experimental models and patients. Therefore, the main aim of this thesis was to gain more insight into the role of immune cells, particularly monocytes, in the reparative responses to acute and chronic ischemic heart disease in patients, and hence, to find new clues for treatment. The results presented in this thesis are derived from clinical studies, autopsy studies, experimental studies and in vitro studies, and were performed in close collaboration with various research groups. This interdisciplinary effort has resulted in a more integrated understanding of how monocytes are involved the reparative responses to acute and chronic ischemic heart disease.
- Note
- Research conducted at: Universiteit van Amsterdam
- Persistent Identifier
- https://hdl.handle.net/11245/1.395590
- Downloads
-
Thesis
Front cover
Title pages
Table of contents
Chapter 1: General introduction and outline of the thesis
Chapter 2: Recovery of microcirculation after intracoronary infusion of bone marrow mononuclear cells or peripheral blood mononuclear cells in patients treated by primary percutaneous coronary intervention: The Doppler substudy of the HEBE trial
Chapter 3: Intracoronary infusion of mononuclear cells from bone marrow or peripheral blood after acute myocardial infarction in patients: The 2-year results from the randomized controlled HEBE trial
Chapter 4: A proinflammatory monocyte response is associated with myocardial injury and impaired functional outcome in patients with ST-segment elevation myocardial infarction: Monocytes and myocardial infarction
Chapter 5: Adverse left ventricular remodelling after acute myocardial infarction in patients is associated with attenuated type I interferon signalling
Chapter 6: Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir
Chapter 7: PET/MRI of inflammation in myocardial infarction
Chapter 8: Suppression of inflammatory signaling in monocytes from patients with coronary artery disease
Chapter 9: Myocardial infarction accelerates atherosclerosis
Chapter 10: Blocking interferon β stimulates vascular smooth muscle cell proliferation and arteriogenesis
Chapter 11: Galectin-2 expression is dependent on the rs7291467 polymorphism and acts as an inhibitor of arteriogenesis
Chapter 12: Summary of the thesis, concluding remarks and future directions
Nederlandse samenvatting
List of publications
Dankwoord
Curriculum vitae
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